Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi.
BACKGROUND. For an effective treatment of vitiligo, it is as important to arrest the progression of the disease (if it is still active) as it is to induce repigmentation in existing lesions. In patients having limited and slow-spreading vitiligo, we evaluated the efficacy of levamisole to control the activity of the disease process and to induce repigmentation of the vitiliginous areas. METHODS. Levamisole was given to 64 patients in an oral dose of 150 mg on two consecutive days every week for periods varying from 4-48 months. In 14 patients levamisole was used alone, in 38 patients it was combined with topical 0.1% fluocinolone acetonide acetate ointment massaged on the lesions once a day, and in 12 patients it was combined with topical 0.05% clobetasol propionate used in the same way. There was no other adjuvant therapy. RESULTS. In 34 of the 36 patients (94%) having active disease, the progression of the disease could be arrested within 2-4 months. A variable degree of spontaneous repigmentation of the vitiliginous areas was seen in 9 patients (64%) treated with levamisole alone, 33 patients (87%) treated with levamisole and topical fluocinolone, and all the 12 patients treated with levamisole and topical clobetasol. The side effects with levamisole were minimal except in two cases where treatment had to be discontinued. Topical fluocinolone was fairly safe in the Indian patients, but clobetasol frequently produced atrophy and telangiectasia. CONCLUSIONS. Levamisole seems to be a simple, safe, and fairly effective remedy for controlling the activity of the disease process in vitiligo patients who have limited and slow-spreading disease. Some patients develop spontaneous repigmentation as well. To achieve a faster rate of repigmentation, levamisole can be combined with other treatment methods such as topical corticosteroids.
Acest articol este preluat de pe o pagina de internet. Concluziile ar fi ca acest Levamisol luat oral ajuta la stoparea evolutiei bolii si la repigmentare in peste 60% si combinat cu aplicare locala a unei solutii cu fluocinolon sau clobetazol, acesta din urma fiind mai eficient dar cu efecte secundare pronuntate, se ajunge pana la 80% stopare si repigmentare.
Acum acest Levamisol din cate am citit este folosit pentru cu totul alte afectiuni… Astept pareri
Prospect : http://www.pcfarm.ro/prospect.php?id=1113
Aticolul original: http://www.ncbi.nlm.nih.gov/pubmed/7960359?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=2&log$=relatedarticles&dbfrom=pubmed